Description
7-OH Extract Powder – High-Purity 7-Hydroxymitragynine for Advanced Research Applications
Product Name: 7-Hydroxymitragynine Extract Powder (7-OH)
Synonyms: 7-OH, 7-HMG, 7-Hydroxy Mitragynine
Active Compound: 7-Hydroxymitragynine
Molecular Formula: C23H30N2O5
Molecular Weight: 414.50 g/mol
CAS Number: 63279-13-2
Purity: ≥98% (HPLC)
Appearance: Fine, beige to light tan crystalline powder
Intended Use: For laboratory and analytical research only. Not intended for human or animal consumption.
Product Overview
7-Hydroxymitragynine (7-OH) is an indole-based alkaloid occurring in minuscule concentrations in Mitragyna speciosa (kratom). Despite its low natural abundance, 7-OH exhibits significantly stronger affinity and activity at μ-opioid receptors than its precursor, mitragynine—reportedly up to 10 times more potent than morphine in preclinical models.
Our 7-OH Extract Powder is synthesized and refined under sterile laboratory conditions, delivering ultra-high purity (≥98%) for pharmacological, neurochemical, and toxicological research. This powder form allows for precision dosing and flexible formulation in a variety of lab protocols.
Chemical and Physical Properties
Structural Highlights:
The compound’s hydroxylation at the 7-position enhances receptor affinity and bioactivity, distinguishing it from other kratom alkaloids.
Solubility Profile:
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Soluble in ethanol, methanol, and DMSO
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Slightly soluble in distilled water
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Insoluble in nonpolar solvents (e.g., hexane)
Melting Point: Approx. 240–250°C (decomposition)
Stability: Chemically stable under dry, dark, cool conditions. Hygroscopic — handle with care.
Pharmacology and Mechanism of Action
7-OH Extract Powder interacts primarily with the central opioid system, specifically:
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μ-Opioid Receptors:
Partial agonist with high efficacy—accounts for the majority of kratom’s analgesic effects at trace levels. -
κ- and δ-Opioid Receptors:
Exhibits moderate to low binding affinity, contributing to its nuanced pharmacological profile. -
Distinct from Traditional Opioids:
Shows potential for reduced respiratory depression and addiction liability due to unique receptor kinetics and G-protein biased signaling. However, these hypotheses are still under investigation.
Applications in Research
7-OH Extract Powder is designed for researchers investigating:
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Opioid Receptor Pharmacodynamics:
Use in receptor binding assays and GTPγS coupling studies. -
Analgesic Mechanism Exploration:
Preclinical studies in acute and chronic pain models. -
Metabolic and Biotransformation Studies:
Examining mitragynine’s in vivo conversion to 7-OH Extract Powder. -
Toxicology and Safety Profiling:
Evaluation of dose-response, LD50 estimation, and adverse effect thresholds.
Sourcing and Synthesis
While trace amounts can be isolated from kratom leaf via advanced chromatography, commercial-grade 7-OH Extract Powder is typically produced via:
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Bioconversion:
Using enzymatic or chemical oxidation of mitragynine. -
Total or Semi-Synthesis:
Controlled laboratory synthesis from mitragynine or related precursors allows for consistent quality, potency, and scalability.
Our extract is rigorously purified, then validated using high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), and mass spectrometry.
Safety and Handling
This compound is a high-potency μ-opioid receptor agonist. It must be handled with full safety protocols in place.
Handling Requirements:
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Nitrile gloves, lab coat, and ANSI-approved eye protection
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Conduct all work in a fume hood
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Use precision balances in microgram range for accurate dosing
Storage Guidelines:
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Store in an airtight container in a cool, dry, and dark environment (2–8°C)
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Avoid exposure to moisture and air
Toxicity Warning:
May be harmful if inhaled or absorbed through skin. Avoid all direct contact. Not approved for consumption. Keep out of reach of unauthorized personnel.
Legal Status
The regulatory status of 7-Hydroxymitragynine is rapidly evolving:
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United States:
Not explicitly scheduled at the federal level but may be restricted under analog or state laws. Handle as a research chemical. -
European Union:
Varies by country; several member states treat it as a controlled substance. -
Asia & Oceania:
Frequently restricted due to association with Mitragyna speciosa and opioid activity.
Researchers are responsible for compliance with all applicable laws and regulations.
Conclusion
7-OH Extract Powder offers researchers a rare and valuable tool for exploring the frontier of opioid receptor pharmacology. With its potent bioactivity, high receptor selectivity, and growing relevance in alternative analgesic research, it stands at the cutting edge of neurochemical investigation.
All batches are quality-assured, purity-tested, and shipped with full documentation, including a Certificate of Analysis (COA) and MSDS.
Not for human or veterinary use. For research purposes only.
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