Description
7OH Tablets – Precision-Dosed 7-Hydroxymitragynine for Analytical and Laboratory Research
Product Name: 7-Hydroxymitragynine Tablets (7OH Tablets)
Synonyms: 7-OH, 7-HMG, 7-Hydroxy Mitragynine
Active Ingredient: 7-Hydroxymitragynine
Molecular Formula: C23H30N2O5
Molecular Weight: 414.50 g/mol
CAS Number: 63279-13-2
Purity: ≥98% (HPLC)
Dosage Form: Compressed tablet (research use only)
Tablet Strength: 5 mg, 10 mg, or custom per tablet
Appearance: Off-white to beige 7OH tablets
Intended Use: For research and analytical purposes only. Not for human consumption.
Product Overview
7-Hydroxymitragynine (7OH tablets) is a highly potent indole alkaloid found in trace amounts in Mitragyna speciosa, commonly known as kratom. It is recognized as one of the most active constituents in terms of opioid receptor binding, exhibiting significantly stronger potency than mitragynine, the parent compound.
Our 7OH tablets offer precise dosing and ease of use for pharmacological and toxicological research, making them ideal for experimental applications requiring consistent and standardized delivery of this compound. Each tablet is manufactured under strict quality control conditions to ensure purity, uniformity, and analytical reliability.
Chemical and Physical Properties
Molecular Structure:
7-OH is a structurally complex monoterpenoid indole alkaloid, featuring a hydroxyl group at the 7-position of the mitragynine backbone. This structural modification significantly enhances its binding affinity to μ-opioid receptors.
Solubility:
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Soluble in ethanol, DMSO, and methanol
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Slightly soluble in water
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Insoluble in nonpolar solvents (e.g., hexane)
Stability:
Stable for up to 24 months under cool, dry, dark conditions. Tablets should remain sealed until use to avoid degradation due to humidity and oxidation.
Pharmacology and Mechanism of Action
7-Hydroxymitragynine is a partial agonist at the μ-opioid receptor, with reported potency estimates ranging from 5x to 13x that of morphine in preclinical models. It also shows affinity for κ- and δ-opioid receptors, though to a lesser extent.
Key Mechanisms:
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μ-Opioid Receptor Agonism:
High-affinity binding leads to strong analgesic and antinociceptive effects in animal studies. -
Low Respiratory Depression Potential:
Unlike classical opioids, 7-OH may exhibit a ceiling effect on respiratory depression, though this is not fully characterized and remains controversial. -
No Significant GABAergic or Dopaminergic Activity:
Unlike other CNS depressants, 7-OH does not directly modulate GABA<sub>A</sub> or dopamine receptors.
Applications in Research
7OH Tablets are suitable for:
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Opioid Pharmacology Studies:
Comparative receptor binding, signal transduction, and efficacy analysis in in vitro and in vivo models. -
Analgesic Screening:
Use in nociceptive and neuropathic pain models to assess analgesic thresholds and duration. -
Toxicology:
Evaluation of safety margins, metabolism, and potential adverse effects. -
Metabolite Tracking:
Study of biotransformation of mitragynine into 7-OH in various species.
Manufacturing and Standardization
Each tablet is produced using high-precision compression equipment, incorporating pharmaceutical-grade excipients for stability and uniformity. The active compound (≥98% pure) is microdosed with exacting accuracy to ensure reproducible results.
A Certificate of Analysis (COA) is provided with every batch, including HPLC chromatograms and potency verification.
Safety and Handling
Protective Measures:
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Use gloves, lab coat, and safety glasses during handling.
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Avoid inhalation of dust or contact with skin.
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Handle in a fume hood when crushing or dissolving tablets.
Storage Guidelines:
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Store in a tightly sealed container in a cool (2–8°C), dry, and dark environment.
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Keep tablets in original packaging to protect from moisture.
Toxicological Note:
7-OH is a highly active opioid compound and must be treated with extreme caution. It poses serious risks if misused or mishandled.
Legal Status
The legal classification of 7-Hydroxymitragynine varies by jurisdiction:
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United States:
Not scheduled federally but may be restricted or regulated in certain states or municipalities. -
Canada & Australia:
Considered a controlled or closely monitored substance under analog laws. -
European Union:
Subject to regulation or prohibition depending on national drug laws.
Researchers are responsible for verifying legality in their local jurisdiction before acquisition or use.
Conclusion
7OH Tablets provide a precise, reliable, and analytically pure form of 7-Hydroxymitragynine, tailored for controlled research environments. Their potent pharmacological profile and receptor specificity make them a valuable tool for advancing the understanding of non-traditional opioids and alternative analgesics.
Strictly for research use only. Not approved for human or veterinary use. Misuse may result in serious harm.
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